I think the simplest way would be to add something like the following action method to a controller:
public class CssController : Controller {
    public ActionResult GetCss() {
        StringBuilder sb = new StringBuilder();
        Dictionary<string, string> cssValues = new Dictionary<string, string>();
        // populate dictionary with values from your database
        sb.AppendLine(".myDivClass {");
        foreach (var entry in cssValues) {
            sb.AppendLine(entry.Key + ": " + entry.Value);
        }
        sb.AppendLine("}");
        return Content(sb.ToString(), "text/css");
    }
}
Now in your page you can reference it like so:
<link href="<%: Url.RouteUrl(new { controller=  "CssController", action = "GetCss" }) %>" rel="stylesheet" type="text/css" />
OP EDIT: I made some small changes to the method, but the general premise remains. This is the version I used:
public class CssController : Controller
{
    public ContentResult GetTheme()
    {
        var builder = new StringBuilder();
        IDictionary<string, IDictionary<string, string>> css = new Dictionary<string, IDictionary<string, string>>();
        /* Populate css object from the database */
        foreach (var selector in css)
        {
            builder.Append(selector.Key);
            builder.Append(" { ");
            foreach (var entry in selector.Value)
            {
                builder.Append(string.Format("{0}: {1}; ", entry.Key, entry.Value));
            }
            builder.AppendLine("}");
        }
        return Content(builder.ToString(), "text/css");
    }
}