Depends on your requirements/existing code.
If you have an existing code infrastructure built on an IoC container, you can in fact combine these with MEF. Recently I've been building an ASP.NET MVC+MEF framework, and a couple of my readers have been asking how to integrate Unity with the MEF+MVC framework I have built. This turned out to be really easy, thanks to a project called the Common Services Locator.
The CSL project is designed to provide an abstraction over service location, so I can grab a CSL provider for Unity, wire it up with a custom ExportProvider and MEF automatically starts composing my IoC-driven parts.
This is one of the benefits of MEFs ExportProvider model, you can easily plug in any additional providers to start pulling exports from a variety of sources.
Last week I blogged about combining MEF+Unity (and also MEF+Autofac as another exmaple), and although my examples are geared up for ASP.NET MVC, the concept is the same for most other implementations.
If you have the option of building something fresh using MEF, you'll probably find that you won't need an IoC container, MEF can handle property injection, constructor injection, part lifetime management, and type resolution.
Let me know if you have any questions :)