I hate to be a downer, but task is impossible to fully accomplish.
If you were somehow able to hook the keyboard (from a silverlight app no-less) I would certainly hope that whatever AV the user is running would throw up some red flags.
Also what if the user doesn't use the standard (alt)+prtscr? A third-party tool might use a different key-combo. Also, I've written a screen-grabber with the GDI+ API, and there's no way to disable something that low-level.
What about attached capture-cards? What if your app is running in a VM or over remote-desktop?
If you are that deeply concerned about protection your HD content, watermark it, or make the user pay for it first.
All-in-all, as soon as your content's data enters your user's computer, they can duplicate it.