I was thinking of centralizing this functionality by having a single method that gets passed an AppState argument and it deals with changing the properties of all GUI elements based on this argument. Every time the app changes its state (ready, busy, downloading so partially busy, etc), this function is called with the appropriate state (or perhaps it's a bit field or something) and it does its magic.
If I scatter changing the state of GUI elements all over the place, then it becomes very easy to forget that when the app is in some state, this other widget over there needs to be disabled too, etc.
Any other ways to deal with this sort of thing?