We had a bunch of computers at work running VS2010 with Resharper. In VS2008, Resharper ran slow enough that all the other devs stopped using it ... even those on quad core boxes and 8GB+ of memory. In VS2010, Resharper 5+ starts up great and works fine ... but then within ~4 hours starts to go downhill. We first notice that simple functions like "Find Usages" return bogus results (or nothing), then it slows down considerably, and finally the mouse stops working (while the keyboard becomes extremely slow). Our project isn't huge either - we only have 5 developers who have been working for a year, so I imagine there are far larger projects using Resharper.
Any suggestions? 4 of the 5 devs on my team have stopped using Resharper altogether, the other is getting ready to. We all have different configurations, computers, and even OS's, but all have similar problems.
Thanks!