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We have just converted our website to run on .NET 4 and upgraded our server (Web Server 2008 SP2 IIS7.0) to run the .NET 4 framework. Our site now displays the following problem on 50% of all computers that try to access it whereas the other 50% work perfectly. All worked fine under .NET 3.5

Sys.WebForms.PageRequestManagerServerErrorException: The requested name is valid, but no data of the requested type was found. ScriptResource.axd Code:0 Line:5 Char:89043

Our web.config has the following defined:

<system.webServer>
  <validation validateIntegratedModeConfiguration="false" />
  <directoryBrowse enabled="true" />
  <modules>
   <remove name="ScriptModule"/>
   <add name="ASPxHttpHandlerModule" type="DevExpress.Web.ASPxClasses.ASPxHttpHandlerModule, DevExpress.Web.v10.1, Version=10.1.5.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a" />
   <add name="ScriptModule" preCondition="managedHandler" type="System.Web.Handlers.ScriptModule, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35"/>
  </modules>
  <handlers>
   <remove name="WebServiceHandlerFactory-Integrated"/>
   <remove name="ScriptHandlerFactory"/>
   <remove name="ScriptHandlerFactoryAppServices"/>
   <remove name="ScriptResource"/>
   <add name="ScriptHandlerFactory" verb="*" path="*.asmx" preCondition="integratedMode" type="System.Web.Script.Services.ScriptHandlerFactory, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35"/>
   <add name="ScriptHandlerFactoryAppServices" verb="*" path="*_AppService.axd" preCondition="integratedMode" type="System.Web.Script.Services.ScriptHandlerFactory, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35"/>
   <add name="ScriptResource" verb="GET,HEAD" path="ScriptResource.axd" preCondition="integratedMode" type="System.Web.Handlers.ScriptResourceHandler, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35"/>
  </handlers>
 </system.webServer>

The site runs with an Application Pool defined as:

.NET Framework Version: v4.0
Managed Pipeline Mode: Integrated

We switched the site to download the Ajax scripts from the MS Content delivery Network (ScriptManager EnableCdn="True") and still had the same problem except this time we get the problem occurring in:

MicrosoftAkaxWebForms.debug.js Line: 868 Char:13

Have removed all our own scripts and the Ajax Control Toolkit to no avail. What is mystifying is that it works ok on 50% of machines and not on the other 50%. There is no commonality between the works/not works. Different o/s different browser mixes. e.g. works fine on one machine Win 7 / IE8 fails on one machine same o/s and browser...works fine on one machine XP Firefox3 fails on another same config.

Any help greatly appreciated (getting desperate!!)

Lastest update:

We reverted the site to .Net 3.5 without changing any code on the site and all works perfectly. Guess we will stick at 3.5 for the foreseeable future!!