If PersistentAttributeInfo is only known at runtime, you obviously cannot write the lambda statically and have the compiler do the heavy lifting for you. You'll have to create a new one from scratch:
Type persistentAttributeInfoType = [TypeYouKnowAtRuntime];
ParameterExpression parameter = Expression.Parameter(persistentAttributeInfoType, "info");
LambdaExpression lambda = Expression.Lambda(
typeof(Func<,>).MakeGenericType(persistentAttributeInfoType, typeof(bool)),
Expression.Equal(Expression.Property(parameter, "Owner"), Expression.Constant(null)),
parameter);
You can invoke lambda.Compile() to return a Delegate that is analogous to the transformed lambda expression in your example (though of course untyped).