I'm having an issue with a Visual Studio 2008 web application project where changes I make to the form or the code behind do not get built when debugging, and so I cannot use breakpoints and in fact none of the changes I make will display unless I navigate to "C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files" and delete the "root" folder therein. So my debugging and development process involves me making changes, then closing Visual Studio 2008, deleting this folder, then re-opening Visual Studio and compiling. I've had the same problem using 2010 as well. My code lives on my C: drive.
Any suggestions are greatly appreciated.