Location directive seems to put the kibosh on Alias in Apache conf

Question

I have a virtual host configured with a Location block and an Alias like so

Alias /lib "/path/to/lib"

<Directory "/path/to/lib">
    AllowOverride None
    Order allow,deny
    Allow from all
</Directory>

<Location />
    SetHandler perl-script
    PerlHandler Plack::Handler::Apache2
    PerlSetVar psgi_app /path/to/webapp/app.psgi
</Location>

Seems like the Location block is rendering the Alias directive ineffective. If I comment out the Location block, the Alias /lib works fine, and I can get to the resources in the /lib folder. If I uncomment the Location block, the /lib alias becomes inaccessible, and I get a 404.

What gives?