Anyone know how I would go about implementing a UI that's very customized, something like this? (Programming in VB.net right now if it matters).
Have yet to deviate from the standard windows form look but I've got a project which I would like to visually style out how I want. Thanks in advance :)
Use WPF.
You can style that however you like.
You will probably be able to find some UI components from companies like Telerik and Infragistics.
With a few custom graphics and controls you should be able to reproduce that with VB.Net, although it's been a while so I can't be more specific.
If you want a free solution for WinForms check out Krypton Toolkit.
It has some nice custom themes..