How to disable all the properties or some of the properties PropertyChanged event for some time when we are using INotifypropertyChanged?
If you are referring to a binding, you can set the UpdateSourceTrigger to Explicit, which means any changes won't get saved until you explicitly tell it to update
<TextBox Text="{Binding SomeValue, UpdateSourceTrigger=Explicit}" />
In order for INotifyPropertyChanged to work, you need to raise the PropertyChanged event. Therefore, to make it not work, you just don't raise that event.
Here's a small example class:
public class NPCExample : INotifyPropertyChanged
{
    public NPCExample()
    {
    }
    private string mSomeProperty = "Set Property";
    public string SomeProperty
    {
        get { return mSomeProperty; }
        set
        {
            mSomeProperty = value;
            if (mUseNotifyPropertyChanged)
                NotifyPropertyChanged("SomeProperty");
        }
    }
    private Boolean mUseNotifyPropertyChanged = true;
    public Boolean UseNotifyPropertyChanged
    {
        get { return mUseNotifyPropertyChanged; }
        set
        {
            mUseNotifyPropertyChanged = value;
            NotifyPropertyChanged("UseNotifyPropertyChanged");
        }
    }
    #region INotifyPropertyChanged Members
    public event PropertyChangedEventHandler PropertyChanged;
    private void NotifyPropertyChanged(string propertyName)
    {
        if (PropertyChanged != null)
            PropertyChanged(this, new PropertyChangedEventArgs(propertyName));
    }
    #endregion
}
In this class, each property calls the common "NotifyPropertyChanged" method for raising the PropertyChanged event. There is an additional variable defined (here, I used a public Property so I could bind it to a checkbox) that tells whether or not to raise the event, as used in the SomeProperty event.
Here's a small, quick-n-dirty program to show this in action: XAML
<Window x:Class="MyNamespace.SelectiveNotifyPropertyChanged"
    xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
    xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
    Title="SelectiveNotifyPropertyChanged" Height="300" Width="300">
    <StackPanel>
        <TextBlock Text="{Binding SomeProperty}" />
        <CheckBox x:Name="chkINPCEnabled"
                  Content="Enable INotifyPropertyChanged"
                  IsChecked="{Binding UseNotifyPropertyChanged}"></CheckBox>
        <StackPanel Orientation="Horizontal">
            <TextBox x:Name="txtIsProperty"
                     Text="Set Property" />
            <Button x:Name="btnSetProperty"
                    Content="Set Property" />
        </StackPanel>
    </StackPanel>
</Window>
Code Behind
using System.Windows.Data;
using System.Windows.Documents;
using System.Windows.Input;
using System.Windows.Media;
using System.Windows.Media.Imaging;
using System.Windows.Shapes;
namespace MyNamespace
{
    /// <summary>
    /// Interaction logic for SelectiveNotifyPropertyChanged.xaml
    /// </summary>
    public partial class SelectiveNotifyPropertyChanged : Window
    {
        public SelectiveNotifyPropertyChanged()
        {
            InitializeComponent();
            NPCExample example = new NPCExample();
            this.DataContext = example;
            btnSetProperty.Click += 
              (s, e) => example.SomeProperty = txtIsProperty.Text;
        }
    }
    public class NPCExample : INotifyPropertyChanged
    {
        public NPCExample()
        {
        }
        private string mSomeProperty = "Set Property";
        public string SomeProperty
        {
            get { return mSomeProperty; }
            set
            {
                mSomeProperty = value;
                if (mUseNotifyPropertyChanged)
                    NotifyPropertyChanged("SomeProperty");
            }
        }
        private Boolean mUseNotifyPropertyChanged = true;
        public Boolean UseNotifyPropertyChanged
        {
            get { return mUseNotifyPropertyChanged; }
            set
            {
                mUseNotifyPropertyChanged = value;
                NotifyPropertyChanged("UseNotifyPropertyChanged");
            }
        }
        #region INotifyPropertyChanged Members
        public event PropertyChangedEventHandler PropertyChanged;
        private void NotifyPropertyChanged(string propertyName)
        {
            if (PropertyChanged != null)
                PropertyChanged(this, new PropertyChangedEventArgs(propertyName));
        }
        #endregion
    }
}
Based on your comment to Rachel it sounds like you might want to set the private property backing member sometimes. Could you expose a public method in your underlying class that would set the private member but not call NotifyPropertyChaged?
Public Class SomeClass
... define property SomeProp and m_SomeProp
 Public Sub SetSomeProp(val as string)
   m_SomePreop=val
 End Sub
End Class