I have a Twisted application that runs in an x86 64bit machine with Win 2008 server.
It needs to be connected to an MSSQL-Server database that runs in another machine (in a cloud actually but I have IP, port, db name, credentials).
Do I need to install anything more that Twisted to my machine?
And which API should be used?
twisted.enterprise.adbapi will help you use any DB-API 2.0 module without blocking. It gives you a non-blocking, Deferred-based API by running database operations in a thread pool. python-mssql appears to be a DB-API 2.0 compliant module for MSSQL (I've never used it myself though).
If you want to have portable mssql server library, you can try the module from www.pytds.com. It works with 2.5+ and 3.1, have a good stored procedure support. It's api is more "functional", and has some good features you won't find anywhere else.