Disclaimer: this is just out of curiosity; I'm no expert at all when it comes to cryptography.
Suppose a 256-bit key is composed of the following (UTF-16) characters:
aaaaaaaabbbbcccc
Futher suppose that an attacker knows the last 4 characters of the key is cccc.
Does this knowledge make it easier for an attacker?
My guess is that it makes it easier for the attacker to brute-force the encrypted text, but my understanding is that brute-forcing AES-256 is a very difficult problem. Then again, there might be something I don't understand about AES itself that makes this type of knowledge more valuable for an attacker.