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New to both Asp.Net 4.0 and IIS7 deployment.

I am having a runtime problem with my application. Basically certain pages are not loading, also looks like a memory issue related to certain calls etc.

What are some of the tools and techniques for profiling/debugging Asp.net 4.0 when deployed on iis7. I am just looking for a way to get the BIG picture and the drill down to smaller level.

Is it suggested that any profiling of value take place in VS2010?