Sessions, suggested by other users, are a basic way of doing things, but are not too reliable. They can also work well in some circumstances, but not in others.
For example, if users are downloading large files or watching videos or listening to the podcasts, they may stay on the same page for hours (unless the requests to the binary data are tracked by ASP.NET too), but are still using your website.
Thus, my suggestion is to use the server logs to detect if the website is currently used by many people. It gives you the ability to:
- See what sort of requests are done. It's quite easy to detect humans and crawlers, and with some experience, it's also possible to see if the human is currently doing something critical (such as writing a comment on a website, editing a document, or typing her credit card number and ordering something) or not (such as browsing).
- See who is doing those requests. For example, if Google is crawling your website, it is a very bad idea to go offline, unless the search rating doesn't matter for you. On the other hand, if a bot is trying for two hours to crack your website by doing requests to different pages, you can go offline for sure.
Note: if a website has some critical areas (for example, writing this long answer, I would be angry if Stack Overflow goes offline in a few seconds just before I submit my answer), you can also send regular AJAX requests to the server while the user stays on the page. Of course, you must be careful when implementing such feature, and take in account that it will increase the bandwidth used, and will not work if the user has JavaScript disabled).