Well with some javascript work,it's quite possible.
First you create a div inside your html side with mouse out event
<div id="tooltip" style="display:none;" onmouseout="hidetooltip();"></div>
then some javascript work is required to insure your when you hover you dropdownlist item it shows a tooltip
function showtooltip(element) {
//select focused elements content to show in tooltip content
document.getElementById("tooltip").innerHTML =
element.options[element.selectedIndex].text;
//show tooltip
document.getElementById("tooltip").style.display = "block";
}
function hidetooltip() {
//hide tooltip
document.getElementById("tooltip").style.display = "none";
}
The last part is adding mouse over and out event to your dropdownlist
<asp:DropDownList ... onmouseover="showtooltip(this)"
onmouseout="hidetooltip()" ... >
Then it should work.You may need to add extra style for your tooltip.
Hope this helps
Myra