+1  A: 

This task is straightforward if you're able to use VBA from within Microsoft Access; e.g.:

DoCmd.TransferSpreadsheet , , _
"tblImportFromExcel","C:\path\to\myfile.xls", True, "A1:B200"

TransferSpreadsheet documentation.

Adam Bernier
I agree that this is the simplest, but couldn't the original poster just make and control an Access object from Excel?
PowerUser
@power: post that as an answer; I'll upvote it if there's a code sample! :-)
Adam Bernier