You can globally enable behavior across the entire document by using a single css rule, and then disable that rule in one statement in javascript, while installing the new event handler.
Add a class to your html body tag:
<html>
<body class="use-hover">
...
Default behavior in your css, let's say to bold links on hover:
body.use-hover a:hover
font-weight: bold
And in your js, when run will remove the default behavior and do something else:
$(function() {
$('body').removeClass('use-hover');
$('a').live('mouseover', function() {
// Do something when hovered
}).live('mouseout', function() {
// Do something after hover is lost
});
});