The basic principle is that used by CSS in web pages.
Rather than ever specifying the formatting (colour / font / layout[to some extent]) of your content, you simply describe what kind of content it is.
To give a web example, in the content for a blog page you might mark different sections as being an:
- Title
- Blog Entry
- Archive Pane
etc.
The Entry might be made of severl subsections such as "heading", "body" and "timestamp".
Then, elsewhere you have a stylesheet which specifies all the properties of each kind of element, size, alignment, colour, background, font etc. When rendering the page or srawing / initialising the componatns in your UI you always consult the current stylesheet to look up these properties.
Then, skinning, and indeed editing your design, becomes MUCH easier. You simple create a different stylesheet and tweak the values to your heat's content.
Edit:
One key point to remember is the distinction between a general style (like classes in CSS) and a specific style (like ID's in CSS). You want to be able to uniquely identify some items in your layout, such as the heading, as being a single identifiable item that you can apply a unique style to, whereas other items (such as an entry in a blog, or a field in a database view) will all want to have the same style.