I bought an Aeron and a Mirra for my home office. (My wife told me I could only spend that kind of money on an office chair if I bought one for her too.)
My wife and I each prefer the Aeron, so we have to fight over it sometimes, but I'd be happy with two Mirras. Note that both of my chairs are fully loaded.
Here are the differentiators:
Aeron:
- better lumbar support
- mesh back
- different sizes available
Mirra:
- adjustable arm widths
- adjustable seat depth
The only real complaint I have about either is that I think the Mirra's plastic back looks awful. But it is not uncomfortable to sit on.