+5  A: 

This API is SOAP based. If you want to use it in a .net application you can just add the web reference and code against it. Seems simple enough as it's basically a one-method API...

Assaf Lavie
I've posted a follow-up question: http://stackoverflow.com/questions/615132/how-might-i-use-the-w3c-markup-validator-api-in-my-net-application
Zack Peterson
I could use a little help parsing the response: http://stackoverflow.com/questions/616817/how-do-i-extract-data-from-an-xml-file-with-visual-basic
Zack Peterson