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Let us say that we have two columns in a spreadsheet. Is it possible to perform set operations on the two columns and save the result in a third column?

For eg.

Col1  Col2  Col3
---------------------
A     B     A
C     D     F
F     C
D

Here Col3 = Col1 - Col2 where "-" is a set operation. Is there a way to do this in Openoffice Calc?