What you're talking about doing is not simple by any stretch.
You're going to need to register a hook, and you're going to have to build a callback procedure that gets called within another process's execution context -- this is not going to be .NET code (probably C instead), and will have to be in a DLL. That callback procedure will get called every time a certain class of events happens. It will examine the events it receives and filter out the ones you're interested, then send your application the notifications you want (probably via PostMessage). You'll then tap in to your application's main message loop to intercept those messages, and from there you can fire a .NET Event, or whatever you want.
Writing hook callbacks is tricky stuff because the code gets run within another process, not your own, and the memory management and concurrency issues take a bit of forethought. For that same reason, it's not going to be done in C#. Ideally, though, this callback code will be very small and very fast, since it's going to get called so often.
Also note that while perfectly "legal" in Win32, these system hooks have an immense amount of power and are commonly used by malware to change the way your system works. For that reason, you may run afoul of antivirus software if you attempt to do this sort of thing on a customer's computer.
Also note that the far-reaching effects of system hooks also means that simple programming mistakes can take down your whole system, which you will probably discover for yourself at some point while debugging; so save everything before you hit "run".
Good luck!
EDIT
Did a bit more search to see if there's any way to write the hook proc in C#, and came up with this:
How to set a Windows hook in Visual C# .NET
This is almost what you're looking for, but not quite. Hook procedures can either be global (which means that they run on every application) or thread (only runs within your application). The document states that:
Global hooks are not supported in the .NET Framework
Except for the
WH_KEYBOARD_LL
low-level hook and the
WH_MOUSE_LL
low-level hook, you cannot
implement global hooks in the
Microsoft .NET Framework. To install a
global hook, a hook must have a native
DLL export to inject itself in another
process that requires a valid,
consistent function to call into. This
behavior requires a DLL export. The
.NET Framework does not support DLL
exports. Managed code has no concept
of a consistent value for a function
pointer because these function
pointers are proxies that are built
dynamically.
Which means, again, to monitor things that go on outside your application's view, you need to set a global hook, which can't be written in .NET.