+3  A: 

Stick to the windows standard.

OK | Cancel | Apply

Use the same size button where possible.

Right align them, below the content of the window.

Use the UI in the Windows Control Panel (Display Settings / Date & Time / Keyboard) as an example.

Eoin Campbell
I'm using this scheme (option #2) but I've seen all of the above options. Even the "Cancel | OK" arrangement. There must be some further reading on this topic. UI should be uniform as much as possible.
Davorin
+2  A: 

Option #2 is fairly standardized. Always put OK before Cancel.

Microsoft recommends 75pix by 23pix for both buttons.

Josh G