This should be fine seeing as the CLR hasn't actually changed?
The boxes running the C# 2.0 code have had .NET 3.5 rolled out.
The background is that we have a windows service (.NET 2.0 exe built with VS2005, deployed to ~150 servers) that dynamically loads assemblies (almost like plug-ins) to complete various work items asked of it. Whenever we roll out a new version of the bus logic, we just drop the assemblies on an FTP server and the windows service knows how to check for, grab and store the latest versions. New assemblies are now built using VS2008 and targetting .NET 2.0, we know that works ok. However we'd like to start taking advantage of C# 3.0 language features such as LINQ and targetting the assemblies against .NET 3.5 without having to build and deploy a new version of the windows service.
Update: @lomaxx - those Albahari lads are fiendishly clever aren't they?