Although I can't give you an exact example in Excel, I'm pretty certain Excel has a function or two to lookup values from any website using a GET request. The difference between a GET and POST request is that in the former all data passed is part of the URL string. Assuming the HTTP support in Excel is basic, I suspect you will have better luck using a GET request, carefully building your URL with the data with simple string manipulation. Although I do not know the exact syntax, imagine a formula in a cell like =lookuphtml("http://some.url.com/send?var1="&B2&"&var2="&B3), where cells B2 and B3 would contain your variable values (the values you want to pass to the script). This assumes the receiving end is capable of receiving data through GET requests (not only POST requests). Most decent server-side libraries allow data passed through both GET and POST request, although YMMV.