This may seem like a strange question...but here goes:
I'm currently working on creating a fairly large site using table-less design/css (obviously the best way to go). Unfortunately, I have a requirement that is completely out of my control that states I must have only one stylesheet for the site.
In some regards this is better because it forces me to think about style re-use pro-actively while designed the pages. On the other hand...the stylesheet is becoming monolithic and I'm quickly losing myself trying to find styles I know I've already defined.
I'd like to do myself (and anybody who has to work on the site in the future) a favor and make the CSS as readable and easy to update as possible. That's where you come in. I'm looking for formatting/organizational suggestions/best practices.
Somebody out there has to be better at it than I am.