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answers:

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I have pdf file contains some text to replace with another text and save the file with new name. Can I do that with iTextSharp? and how? Can you give me guid for it?

A: 

Generally speaking this is not possible. Check out this FAQ question which discusses the issue. The FAQ addresses iText (the Java version project from which iTextSharp was derived) but applies to iTextSharp as well.

Jay Riggs