I've been trying to work out why our pages load slowly, and one thing I've noticed in Fiddler is that each page load for /mysite/mypage.aspx brings with it a request for GET /mysite/null HTTP/1.1, resulting in a 404 error.
I'm guessing this 404 error on every page load is slowing the site down even further, are there any ways of debugging what might be causing this? We use lots of Ajax/Javascript.
Similar question: http://stackoverflow.com/questions/539177/what-is-the-source-of-path-null-requests, ours is slightly different because it reliably happens on every page load