We have a large winforms program. On one computer if you are running the program and open IE8 the winforms program freezes and doesn't come back. But if you already have IE8 running when you start the winforms program everything appears to be fine.
The same thing happens regardless of how you start IE8 (normal, no addins, or 64 bit).
My dev box has the same os, motherboard, processor, and memory and it runs fine.
This is on Vista Enterprise x64 Q9550 with 8GB ram.
It runs fine with Firefox 3. The weird thing is there are no web browser controls in the app or anything that should make it related to IE.