Depends on whether you're an object or relational modeler. Preference is dictated by what you know best.
I'm an object person, so I'd say model the problem in objects and then get the relational schema from that.
I think there are lots of issues around data that aren't addressed by objects (e.g., indexing, primary and foreign keys, normalization) that say you still have some work to do when you're finished.
But any relational person will argue that they're primary and should be in the driver's seat.
I doubt that there will be a definitive answer to this one. I don't believe there should be. There's an object-relational impedance mismatch that's real. Objects are instance-centric; relational models are set-based. Both need careful consideration.