I would like to open a new MonoDevelop instance to work on a different project on the Mac, and the OS is currently preventing me from opening a new instance.
On Mac, if you have an app open and you try to launch it again, the Mac just switches to the open app. You can force it to open a new instance by passing the option "-n" to the launcher. In a terminal, run
open -n /Applications/MonoDevelop.app
Note also that MonoDevelop is capable of opening multiple solutions. To do this, simply uncheck the "close current dialog" checkbox in the "Open" dialog, or hold down the control key when clicking on one of the recently opened projects in the Welcome Page.
For convenience, I just create three copies of MonoDevelop.
Highlight MonoDevelop in Finder, copy, paste, rename the new copy to "MonoDevelop-2", and repeat to your satisfaction.
It also helps me keep track of what's going on in different instances. I typically keep my most important project open in "MonoDevelop", use "MonoDevelop-2" for testing ideas related to my main project, and "MonoDevelop-3" for random scratch.
When you alt-tab (open-Apple-tab (command-tab (whvr))), the name of the executable shows up beneath its icon in the application list, so, as long as I stick to my convention, I always know(ish) the contents of the instance I'm alt-tabbing to regardless of how many other app windows I have open. I don't have to cycle through them to figure it out.
It's not perfect - when I have "MonoDevelop" running, if I try to fire up one of the others, the first attempt to start will fail. You just try to fire it up again - it works the second time. This has only been happening since the most recent build, though, and I think it might have something to do with automatic updates or add-in management. Haven't looked into it too much. Since there are no problems once up and running, I don't worry about it :)
The result is that, with the start-it-twice method, for any additional instance of MonoDevelop you'd like to start, you end up having to quadruple-click instead of double-click. Adds about fifteen seconds to the process, and since I have MonoDevelop (along with "MonoDevelop-1" and "MonoDevelop-2") running all the time, it adds up to, maybe, an extra thirty seconds of work each week. A fair trade for the convenience, methinks.
A bit hacky, but it's worked well for me.
And all the cool kids are doing it.