CSS frameworks have nice styles inbuilt and ask you to focuses on the grids but still there is a bit of dependency and lack of freedom it provide.. If I need to generate a webpage by looking on a PSD based mockup screen ..either i will use the classes provided by the framework but if that actual measurements does not exist I need to again specify my own rules that will add upto my CSS filesize and if performance is a constraint as always it is...you need not a big size file..though its in kb but every drop counts.
Any comments and suggestions to use the framework in a best possible way.