Hmmm, difficult question to answer imho.
I don't think that tools like 'the entity framework' will lead to bringing up a generation of developers that do not understand the principles of relational database design.
First and foremost, object oriented design is already a long time around, and people have been searching for solutions to bridge the gap between OO and RDBMS'es for ages.
I don't see 'entity driven design' as you call it (I'd rather call it domain driven design), replace relational DB design. In fact, for me those 2 things will continue to live next to each other, as both technologies are -IMHO- the best solution for the problem they're trying to solve:
- OO is the perfect way to model data + behaviour
- the relational model is the perfect way to efficiently store data and run queries on it.
If you want to be successfull in creating an application in a domain driven fashion (using an O/R mapper like NHibernate or the entity framework), it is still necessary that you - the developer - have a basic understanding and knowledge of how the relational model works.
In fact, you're still talking to a relational database, albeit through the O/R mapper.
If you want have a well performing application, you'll have to know that a relational database is set based, for instance; that it is not a good idea to perform a SELECT n + 1 query, etc...
In fact, I'm using an O/R mapper (NHibernate) for one year (professionaly), and I've been playing with it for a few years, but I still prefer to create my relational data model by hand. I do not generate my DB model through my O/R mapper via the classes I've written, since I'd like to be in control.
So short answer: I think it will still be required that a developer understands the relational model if he wants to be successfull using an O/R tool.