There is definitely a way. I think its just a matter of tweaking the CSS to either add in another 400px column, or modifying an existing column to fit your needs. If you are adding another column, be sure to account for the additional width (plus margin) and either reduce width on other elements, or increase the width of your containing element.
If the layout is using 100% width of the browser, width may not be an issue, but if your content is wrapped in a container element which holds all of your columns, be sure to adjust the existing elements to make up for the size of your new column.
EDIT: Also if you are dealing with 100% width layouts, its probably better to size your columns using percentage, instead of a fixed pixel size. Since the containing element for your columns will be the user's screen, if you use percentage then the column sizes should adjust relative to their resolution/window size.
If you want your new column to appear on the left of the your other columns, typically you would place it before the other columns in your markup, and apply a "float:left" property. But, take a look at how the other columns are set up in the YUI CSS, and follow their method.
I hope that helps.
Acorn