I second Treb's answer and suggest one further thought - the big thing I see lacking in many remote degrees is team work. When I do software engineer interviews as a hiring manager, I look for someone who can work in my team. The way I do that is to talk to the person about their prior experiences working on hard problems, under stress, within teams. When I hear stories that suggest that this person is good at learning from others, mentoring, listening, and explaining his thoughts -- then I know I have a winner.
If your prior experience is in very solitary positions, I would suggest you think somewhat about how to get some technical team experience. On-site college education is a way to do that -- most of the leading tech colleges these days have numerous (often required) team-focused courses. That gives you a lot to talk about in that next job interview.
If distance learning is the only feasible option for your current life situation, check with the school and see if they have classes that allow remote teams to work together -- after all, with software there's no requirement that everyone be in physically the same location!! (although that is easier) And being able to work remotely as part of a team would be a really good skill to have -- even with our whole team in one place jobs, my company has needs for people who can work with remote engineers.
Failing that, look to be part of some sort of extracirricular effort - a job, an open source project, a startup or any other volunteer work - that is both technical and includes a team of technical people.
As a manager, I don't care where you get your team work skills -- only that you have them!
For a point of reference - I did my undergrad in the traditional way from an institute of tech. And my grad work was done all off-site (although in a classroom format) - I stepped on campus 3 times - once to grab a hard to find book, once to pickup cap & gown, and once to attend graduation. Both schools offered both distance and on-site degrees. The diplomas and the paperwork look exactly the same, and there would be no reason to specifically call out the distance aspect of the graduate work on a resume.