I've made an MVC style Javascript program. Complete with M and C. Maybe I made a wrong move, but I ended up authoring my own event dispatcher library. I made sure that the different tiers only communicate using a message protocol that can be translated into pure JSON objects (even though I don't actually do that translation step).
So jquery lives primarily in the V part of the MVC architecture. In the M, and C side, I have primarily code which could run in the stand alone CLI version of spidermonkey, or in the serverside rhino implementation of javascript, if necessary. In this way, if requirements change later, I can have my M and C layers run on the serverside, communicating via those json messages to the V side in the browser. It would only require some modifications to my message dispatcher to change this though. In the future, if browsers get some peer to peer style technologies, I could get the different teirs running in different browsers for instance.
However, at the moment, all three tiers run in a single browser. The event dispatcher I authored allows multicast messages, so implementing an undo feature now will be as simple as creating a new object that simply listens to the messages that need to be undone. Autosaving state to the server is a similar maneuver. I'm able to do full detailed debugging and profiling inside the event dispatcher. I'm able to define exactly how the code runs, and how quickly, when, and where, all from that central bit of code.
Of course the main drawback I've encountered is I haven't done a very good job of managing the complexity of the thing. For that, if I had it all to do over, I would study very very carefully the "Functional Reactive" paradigm. There is one existing implementation of that paradigm in javascript called flapjax. I would ensure that the view layer followed that model of execution, if not used specifically the flapjax library. (i'm not sure flapjax itself is such a great execution of the idea, but the idea itself is important).
The other big implementation of functional reactive, is quartz composer, which comes free with apple's developer tools, (which are free with the purchase of any mac). If that is available to you, have a close look at that, and how it works. (it even has a javascript patch so you can prototype your application with a prebuilt view layer)
The main takaway from the functional reactive paradigm, is to make sure that the view doesn't appear to maintain any kind of state except the one you've just given it to display. To put it in more concrete terms, I started out with "Add an object to the screen" "remove an object from the screen" type messages, and I'm now tending more towards "display this list of objects, and I'll let you figure out the most efficient way to get from the current display, to what I now want you to display". This has eliminated a whole host of bugs having to do with sloppily managed state.
This also gets around another problem I've been having with bugs caused by messages arriving in the wrong order. That's a big one to solve, but you can sidestep it by just sending in one big package the final desired state, rather than a sequence of steps to get there.
Anyways, that's my little rant. Let me know if you have any additional questions about my wartime experience.