Not depending on the framework you'll chose, the first thing you have to know is that :
- it'll take some time for you to know it
- you'll do crapping things, during that time ^^
- so, take into account the fact it'll take some time before you are fully operational :-)
I think those points are the most under-estimated points : using a framework takes not much time... Using it well and to the full extend of its abilities takes... Well, a couple of months, maybe... Which means, when you are at the end of your project you'll say "I should rewrite that with all the stuff I learned while re-writing it the first time" :-D
What it means is : learn what the framework can do, learn how to use it, and use it for a while on small applications, before starting rewriting your big one !
Then, there is probably no "best framework" : one framework may be very well suited for one project, and another one may be best for a second, different project.
I've never worked with CakePHP ; I really like Zend Framework. But that is a personal opinion, and O know people who really like symfony ; they are not wrong : symfony is great -- and I am not wrong either ^^
Still, we sometimes agree on some things ; like the fact that Doctrine (default ORM layer of symfony) is really great stuff, and we tend to use in both symfony and ZF-based projects...
If motivated, you can take a look at many posts on SO, about frameworks... Here are a couple of those :
Good luck with those ^^
("Which framework" is a quite pationnating -- and subjective -- question ^^ )