Consider Wing IDE -- IMHO the best commercial IDE for Python, it does support Django if that's what you want (as, apparently, do 80% of Python-based websites; personally, I prefer werkzeug and the like, but maybe that's partly because my "web apps" tend to be more like "web services", with most all the UI/views parts done in HTML/CSS/Dojo;-).
Me, I use Vim (usually in the gvim incarnation) as my "Python IDE" (and I've seen Emacs-using colleagues do at-least-equivalent wizardry, but I just can't get used to Emacs myself!-)... but I have to admit that a Wing IDE expect, particularly if faced with a thorny debug scenario, can do circles around me (and even around the Emacsers). ((So why haven't I made the effort to switch? Maybe because, thanks to fanatical testing, I now face thorny debug scenarios too rarely to make me an expert in any new tool!-)) ((Or maybe because my fingers, having learned vi 30+ years ago, would HATE me if I switched to ANYTHING else;-)).