One way is to look at maxint:
$ /usr/bin/python2.6
Python 2.6.1 (r261:67515, Jul 7 2009, 23:51:51)
[GCC 4.2.1 (Apple Inc. build 5646)] on darwin
Type "help", "copyright", "credits" or "license" for more information.
>>> import sys; sys.maxint
9223372036854775807
>>> ^D
$ arch -i386 /usr/bin/python2.6
Python 2.6.1 (r261:67515, Jul 7 2009, 23:51:51)
[GCC 4.2.1 (Apple Inc. build 5646)] on darwin
Type "help", "copyright", "credits" or "license" for more information.
>>> import sys; sys.maxint
2147483647
[EDIT] BTW, if you run into a 64-bit universal build of Python3 on OS X, this trick won't work because sys.maxint has been removed in Python3. However, for Python3 you can use sys.maxsize instead with the same results. Don't use sys.maxsize for Python2.6, though, as it appears not to be dynamically determined. Ugh.