Well yes i know this is an anecdotal question - and if you want to close, do it.
But i'm hunting one for 18 month now. Everytime when i think i have a reproduceable use case i have someone coming in telling me we have other things to do.
The longest "on session" time seems to be yesterday 2 full working day to track down a multithreading race condition that only appeared the first time after installation of the program - luckily this time it was reproduceable. So i had to created builds after builds, reseting a VMWare image about a feeled 23434 times.
Only reason why i did it was that i had no milestone for the next 45 days so i took my time.
But i wonder if other people or development groups had opened a bug hunting season for a single bug. I remember one company where i worked in the past they had a very nasty memory leaking bug in Java and offered a month salary for the guy who fixed it - but never allowed regular working time to track it down. I think this bug is still alive today - 8 years after i left the company.