It depends a little on what you're trying to do.
If runtime speed is your issue then c++ is the best way to go.
If speed of development is an issue, though, I would suggest looking at java. You said that you wanted low level manipulation of pixels, which java will do for you. But the other thing that might be an issue is the handling of the various file formats. Java does have some very nice APIs to deal with the reading and writing of various image formats to file (in particular the java2d library. You choose to ignore the higher levels of the API)
If you do go for the c++ option (or python come to think of it) I would again suggest the use of a library to get you over the startup issues of reading and writing files. I've previously had success with libgd