Here's an adapted example of programmatic configuration from Quartz.NET's example 13:
NameValueCollection properties = new NameValueCollection();
properties["quartz.scheduler.instanceName"] = "TestScheduler";
properties["quartz.scheduler.instanceId"] = "instance_one";
properties["quartz.jobStore.type"] = "Quartz.Impl.AdoJobStore.JobStoreTX, Quartz";
properties["quartz.jobStore.useProperties"] = "true";
properties["quartz.jobStore.dataSource"] = "default";
properties["quartz.jobStore.tablePrefix"] = "QRTZ_";
// if running MS SQL Server we need this
properties["quartz.jobStore.lockHandler.type"] = "Quartz.Impl.AdoJobStore.UpdateLockRowSemaphore, Quartz";
properties["quartz.dataSource.default.connectionString"] = "Server=(local);Database=quartz;Trusted_Connection=True;";
properties["quartz.dataSource.default.provider"] = "SqlServer-20";
// First we must get a reference to a scheduler
ISchedulerFactory sf = new StdSchedulerFactory(properties);
IScheduler sched = sf.GetScheduler();
You can also achieve the same thing with properties file based approach (the .config file).