It is common to represent status of an item in a GUI using the colors: red, yellow, green, to mean error, warning, and OK (or something equivalent). However, 7-10% of men have difficulty distinguishing between red and green because of color blindness.
So far I've looked at Color Scheme Designer which simulates how people with different color blindnesses would perceive a set of colors, but I'm interested in hearing how you have approached this problem and how successful it was.