The short answer, as @THC4K points out in a comment:
string.split(pattern, 1)[0]
where string is your original string, pattern is your "break" pattern, 1 indicates to split no more than 1 time, and [0] means take the first element returned by split.
In action:
>>> s = "a descriptor 23 fd"
>>> s.split("23", 1)[0]
'a descriptor '
>>> s.split("fdasfdsafdsa", 1)[0]
'a descriptor 23 fd'
This is a much shorter way of expressing what I had written earlier, which I will keep here anyway.
And if you need to remove multiple patterns, this is a great candidate for the reduce builtin:
>>> string = "a descriptor dps foo 23 bar fd quux"
>>> patterns = ["dps", "23", "fd"]
>>> reduce(lambda s, pat: s.split(pat, 1)[0], patterns, string)
'a descriptor '
>>> reduce(lambda s, pat: s.split(pat, 1)[0], patterns, "uiopuiopuiopuipouiop")
'uiopuiopuiopuipouiop'
This basically says: for each pat in patterns: take string and repeatedly apply string.split(pat, 1)[0] (like explained above), operating on the result of the previously returned value each time. As you can see, if none of the patterns are in the string, the original string is still returned.
The simplest answer is a list/string slice combined with a string.find:
>>> s = "a descriptor 23 fd"
>>> s[:s.find("fd")]
'a descriptor 23 '
>>> s[:s.find("23")]
'a descriptor '
>>> s[:s.find("gggfdf")] # <-- look out! last character got cut off
'a descriptor 23 f'
A better approach (to avoid cutting off the last character in a missing pattern when s.find returns -1) might be to wrap in a simple function:
>>> def cutoff(string, pattern):
... idx = string.find(pattern)
... return string[:idx if idx != -1 else len(string)]
...
>>> cutoff(s, "23")
'a descriptor '
>>> cutoff(s, "asdfdsafdsa")
'a descriptor 23 fd'
The [:s.find(x)] syntax means take the part of the string from index 0 until the right-hand side of the colon; and in this case, the RHS is the result of s.find, which returns the index of the string you passed.