I've tried searching for this but it's pretty difficult to put into words.
Basically, our site will run fine for most users without any issues. Sometimes though, those of us who use the site pretty heavily all day will suddenly get completely bogged down. Everything just spins in place. The site itself is still fine - everyone else can still get to it, but the individual user is stuck. In fact, restarting the browser entirely doesn't generally fix the issue, even if you explicitly clear your cookies.
You can, however, generally open the site just fine by switching to a different browser. If you're bogged down in Firefox, you can usually open it up and continue working just fine in IE. This can happen both ways (you can bog down IE, and switching to firefox works).
Does this make any sense at all? It's like there's something breaking with the session, but I don't know what would cause this and the session should reset by restarting the browser and clearing cookies and whatnot.
Any ideas?
[Editing to clarify, sorry, should have included this to begin with] Server is a very basic LAMP stack on RedHat with Apache 2.2.3, PHP 5.2.11, MySQL 5.0.45 (we've considered upgrading MySQL but I don't think this is the issue here). It's a standard configuration for Rackspace, so I don't think we're doing anything exotic besides maybe the Zend Optimizer.
We're using a lot of javascript/jquery but it's all pretty standard stuff and I wouldn't expect a memory leak to not affect the other browser, though I may be wrong.
Also, our server's CPU and memory usage have never broken the 25% margin, even in spikes, and the spikes don't seem to correlate with this phenomenon.