The coolest CSS framework I know about is LESS. It allows you to add variables, inheritance, arithmetic operations, and other coolness using CSS-like syntax-- and it "compiles" down to regular CSS using a build step or server plugin.
Like C to C++, LESS's syntax is backwards-compatible to CSS, so you can simply rename all your .CSS files to .LESS and start adding LESS functionality without learning a whole new language.
As the comments note below, Rails and PHP support LESS already via server plugins. There's also an ASP.NET port in Beta. There's also apparently Django support. And Cold Fusion. And so on...
Note that using LESS (as a Ruby executable which spits out CSS files) can be as simple as running it to compile .LESS files into .CSS as part of your build process. The build machine has to be able to run Ruby of course, unless you're using one of the plugins which ported the LESS compiler to that platform's natural code.
Note that xCSS offers similar features to LESS-- I'd not heard about xCSS though. AFAIK LESS is more popular, but others in the community here can weigh in since popularity changes fast!