Demo: http://www.simpsoncrazy.com/characters/poster2
(Using Map Hilight plugin: http://plugins.jquery.com/project/maphilight)
When you click a quadrant of the image, it should zoom in on that image, however in IE8 (regular and compat mode) the "zoomed" images never load. Also on the top-left segment the right arrow appears on the left.
I've looked at Firebug and IE Dev Tools but they seem largely the same apart from differing opacity definitions (IE uses filters).