M2Cypto has a FTPS module. From the documentation:
>>> from M2Crypto import ftpslib
>>> f = ftpslib.FTP_TLS()
>>> f.connect('', 9021)
'220 spinnaker.dyndns.org M2Crypto (Medusa) FTP/TLS server v0.07 ready.'
>>> f.auth_tls()
>>> f.set_pasv(0)
>>> f.login('ftp', 'ngps@')
'230 Ok.'
>>> f.retrlines('LIST')
-rw-rw-r-- 1 0 198 2326 Jul 3 1996 apache_pb.gif
drwxrwxr-x 7 0 198 1536 Oct 10 2000 manual
drwxrwxr-x 2 0 198 512 Oct 31 2000 modpy
drwxrwxr-x 2 0 198 512 Oct 31 2000 bobo
drwxr-xr-x 2 0 198 14336 May 28 15:54 postgresql
drwxr-xr-x 4 100 198 512 May 16 17:19 home
drwxr-xr-x 7 100 100 3584 Sep 23 2000 openacs
drwxr-xr-x 10 0 0 512 Aug 5 2000 python1.5
-rw-r--r-- 1 100 198 326 Jul 29 03:29 index.html
drwxr-xr-x 12 0 0 512 May 31 17:08 python2.1
'226 Transfer complete'
>>> f.quit()
'221 Goodbye.'
>>>
Alternatively, if you wanted to minimise use of third-party modules, you should be able to subclass the standard library's ftplib.FTP class with the built-in (to Python) SSL support. M2Crypto (or Twisted, if you want to go that way) is the easier solution, though.