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I'm trying to implement the proper architecture for multiple databases under Python + Pylons. I can't put everything in the config files since one of the database connections requires the connection info from a previous database connection (sharding).

What's the best way to implement such an infrastructure?

+1  A: 

Pylons's template configures the database in config/environment.py, probably with the engine_from_config method. It finds all the config settings with a particular prefix and passes them as keyword arguments to create_engine.

You can just replace that with a few calls to sqlalchemy.create_engine() with the per-engine url, and common username, and password from your config file.

joeforker